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Environ Health Perspect 2007

Classification of these pathways according to the involved pathological process revealed a broad division into inflammation-related pathways (chemokine signaling, cytokine-cytokine receptor interaction, MAPK signaling, Toll-like receptor signaling, NOD-like receptor signaling, NF-B signaling, etc.), metabolism-related pathways (phagosome, PI3K-AKT signaling, etc.), and fibrosis-related pathways (ECM-receptor interaction) (Figure 7C)

The vasodilatory actions of NO play a prominent role in this process (143)